DARE (DigitAl lifelong pRevEntion) is a wide-ranging initiative funded by the Italian Ministry for University & Research. Its goal is to create and develop a connected and distributed knowledge community for digital preventive healthcare through research, innovation, and the participation of multiple stakeholders. The initiative is producing, collecting, and systematizing multidisciplinary knowledge and solutions (technical, ethical-legal, and organizational) necessary to affirm Italy as a leading country in digital prevention.